When a young man witnesses a brutal mob murder, it falls to FBI agent Neville Flynn to escort
his charge safely from Hawaii to Los Angeles to testify. But in an act of self-preservation, the
crime boss facing prison smuggles hundreds of poisonous snakes onto the commercial aircraft in
a crate timed to release its deadly cargo halfway over the Pacific. Flynn, along with a
frightened flight crew and passengers, must then band together in a desperate attempt to
survive.