Sam "Ace" Rothstein, the consummate bookie who can change the odds merely by placing a bet, has risen through the ranks of the Midwestern mob to be picked by the bosses to front their entree into Vegas. Ace lives and breathes the odds. He eventually doubles the mob's take and changes the rules of how the casinos are run. But he can't control the odds when it comes to Ginger McKenna, the chip-hustling vamp who charms Ace and becomes his wife. His infatuation with Ginger turns to obsession as she rises with him to the upper crust of society, then turns to the bottle and pills for consolation in her gilded cage. The third member of this
triangle of greed and obsession is Nicky Santoro, Ace's best friend and fellow graduate of the city streets. Together, they run the perfect operation, with Ace in charge and Nicky providing the muscle. But as Nicky expands his interests and each man gains power, their lives become entangled in a story of hot tempers, obstinacy, money, love and deception.