Johnny Galecki (ROSEANNE) and Jim Parsons (JUDGING AMY) star as two geeky scientists who are accustomed to probing the secrets of the universe, but totally inept when it comes to the greatest mystery of all: women. Their lives are turned upside down with the arrival of Penny (Kaley Cuoco), a beautiful blonde who moves in next door and gets their Bunsen burners all fired up. Plenty of high jinks ensue as the two clueless roommates receive a crash course in the ways of the opposite sex.
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